Matthew Gazzara  |  Research Specialist  |  mgazzara@upenn.edu

BIO

I received my bachelor’s degree in Biology from the University of Pennsylvania in 2012. As an undergraduate I worked in the laboratory of Dr. Paul Sniegowski where I used theoretical population genetics and experimental evolution to study the evolution of mutation rates. I received the Joseph Leidy Award for Research Achievement for my honors thesis work examining the effects of horizontal gene transfer mediated recombination on mutation rate evolution in experimental E. coli populations. After graduating I have continued pursuing my broad interest in molecular biology as a joint member of the Barash and Lynch labs. I am currently focused on using computational models to identify and experimentally verify novel regulatory mechanisms of neuronal, muscle, and T-cell alternative splicing.

Topics

​· Alternative Splicing Quantification

· Regulatory Elements Modeling
· Computational biology

Publications

In silico to in vivo splicing analysis using splicing code models | Gazzara M.R., Vaquero-Garcia J., Lynch K.W., Barash Y.

Methods. 2013 | Google Scholar | URL

Contrasting dynamics of a mutator allele in asexual populations of differing size | Raynes Y., Gazzara M.R., Sniegowski P.D.

Evolution. 66(7):2329-2334. 2012 | Google Scholar | URL

Mutator dynamics in sexual and asexual experimental populations of yeast | Raynes Y., Gazzara M.R., Sniegowski P.D.

BMC Evolutionary Biology. 11:158. 2011 | Google Scholar | URL

© BIOCIPHERS - 2020 · Department of Genetics Perelman School of Medicine Department of Computer and Information Science School of Engineering University of Pennsylvania