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​   Publications

2023

CHESSBOARD: a Bayesian model for unsupervised detection of alternative splicing based subtypes in heterogeneous cancers

Wang D., Quesnel-Vallières M., Jewell P., Elzubier M., Lynch K.W., Thomas-Tikhonenko A., Barash Y.

Nature Comm. Vol 14 Issue 1

URL

RNA splicing analysis using heterogeneous and large RNA-seq datasets

Vaquero-Garcie J.*, Aicher J.K.*, Jewell P.*, Gazzara M.R.*, Radens, C.M.^, Jha, A.^, Green C.J., Norton S., Lahens N.F., Grant, G.R., Barash Y.

Nature Comm, in press

2022

The germ cell-specific RNA binding protein RBM46 is essential for spermatogonial differentiation in mice

Peart N. et al.

Plos Genetics. Vol 18 Issue 9

FBXW7β isoform drives transcriptional activation of a proinflammatory TNF cluster in normal and malignant pro-B cells

Yang SY, Hayer KE, Fazelinia H, Spruce LA, Asnani M, Black KL, Naqvi AS, Pillai V, Barash Y, Elenitoba-Johnson KSJ, Thomas-Tikhonenko A

Blood Advances,

The global Protein-RNA interaction map of ESRP1 defines a post-transcriptional program that is essential for epithelial cell function

Peart N. et al.

iScience. Vol 25 Issue 10

Identifying common transcriptome signatures of cancer by interpreting deep learning models

Jha A.*, Quesnel-Vallières M.*, Wang D., Thomas-Tikhonenko A., Lynch K.W., Barash Y.

Genome Biology

High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance

Cortés-López M. et al.

Nature Comm. Vol 13 Issue 1

2021

Modulation of CD22 protein expression in childhood leukemia by pervasive splicing aberrations: implications for CD22-directed immunotherapies

Zheng S. et al.

Blood Cancer Discovery

Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia

Rivera, O.D., Mallory, M.J., Quesnel-Vallières, M., Chatrikhi, R., Schultz, D.C., Carroll, M., Barash, Y., Cherry, S., Lynch, K.W.

Proc Natl Acad Sci USA 118, e2014967118

CAMPAREE: a robust and configurable RNA expression simulator

Lahens N. F. et al

BMC Genomoics Vol 22 Issue 1

Disrupting upstream translation in mRNAs is associated with human disease

Lee, D.S.M., Park, J., Kromer, A., Baras, A., Rader, D.J., Ritchie, M.D., Ghanem, L.R., Barash, Y

Nature Comm. 12, 1515

CYP11B1 Variants Influence Skeletal Maturation Via Alternative Splicing

Grgic O.*, Gazzara R. M.* et al

Nature Comm. Bio. Vol 4, Issue 1

MOCCASIN: A method for correcting for known and unknown confounders in RNA splicing analysis

Slaff, B., Radens, C.M., Jewell, P., Jha, A., Lahens, N.F., Grant, G.R., Thomas-Tikhonenko, A., Lynch, K.W., Barash, Y.

Nature Comm. Vol 12 Issue 1

RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis

Ji, X., Jha, A., Humenik, J., Ghanem, L.R., Kromer, A., Duncan-Lewis, C., Traxler, E., Weiss, M.J., Barash, Y., Liebhaber, S.A.

Mol Cell Biol 41

The Global Protein-RNA Interaction map of Epithelial Splicing Regulatory Protein 1 defines a post-transcriptional program that is essential for epithelial cell function

Peart, N.J., Hwang, J.Y., Vallières, M.Q.-, Sears, M.J., Yang, Y., Stoilov, P., Barash, Y., Park, J.W., Carstens, R.P

Cell Reports, in press

Direct long-read RNA sequencing identifies a subset of questionable exitrons likely arising from reverse transcription artifacts

Schulz, L., Torres-Diz, M., Cortés-López, M., Hayer, K.E., Asnani, M., Tasian, S.K., Barash, Y., Sotillo, E., Zarnack, K., König, J., Thomas-Tikhonenko, A

Genome Biology 22, 190

2020

Mapping RNA splicing variations in clinically accessible and nonaccessible tissues to facilitate Mendelian disease diagnosis using RNA-seq.

Aicher J.K , Jewell P., Vaquero-Garcia J., Barash Y., and Bhoj E.J

Genet Med (2020)

Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations.

Lee, D.S.M., Ghanem, L.R. & Barash, Y.

Nature Com. 11, 527 (2020).

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Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases

Nurnberg ST, Guerraty MA, Rao HS, Pjanic M, Norton S, Serrano F, Perisic L, Elwyn S, Pluta J, Zhao W, Testa S, Park Y, Wang T, Hedin U, Sinha S, Barash Y, Brown CD, Quertermous T, and Rader DJ.

PLoS Genet 16(1): e1008538.

Enhanced Integrated Gradients: improving interpretability of deep learning models using splicing codes as a case study

Jha A., Aicher J.K, Singh D. and Barash Y.

Genome Biology, 21, 149 (2020)

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Rapid and scalable profiling of nascent RNA with fastGRO

Barbieri E., Hill C., Quesnel-Vallieres M., Barash Y., Gardini A.

Cell Reports, Vol 33, Issue 6

Meta-Analysis of Transcriptomic Variation in T cell Populations Reveals Novel Signatures of Gene Expression and Splicing

Radens C.M, Blake D., Jewell P., Barash Y.* and Lynch K.W.*

RNA 10.1261 2020

2019

An ancient germ cell-specific RNA binding protein protects the germline from cryptic splice site poisoning

Ehrmann I., Crichton J.H., Gazzara M.R. 3,4, James K., Liu Y., Grellscheid S., Curk T., de Rooij D.G., Steyn J., Cockell S.J., Adams I.R, Barash Y. and Elliott D.J

ELife, 2019;8:e39304

URLGoogle Scholar | URL

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Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19

Asnani, M., Hayer, K.E., Naqvi, A.S. et al.

Leukemia (2019)

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2018

RNA-binding protein A1CF modulates plasma triglyceride levels through posttranscriptional regulation of stress-induced VLDL secretion

Lin, J., Conlon, D.M., Wang, X., Nostrand, E.V., Robano, I., Park, Y., Strong, A., Radmanesh, B., Barash, Y., Rader, D.J., Yeo, W. Y, Musunuru K.

Submitted

Aberrant splicing in B-cell acute lymphoblastic leukemia

Black, K.L., Naqvi, A.S., Hayer, K.E., Yang, S.Y., Gillespie, E., Bagashev, A., Pillai, V., Tasian, S., Gazzara, M.R., Carroll, M., Taylor D., Lynch K. W., Barash Y., Thomas-Tikhonenko A.

Nucleic Acids Res 46, 11357–11369

Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript

Ghanem LR, Kromer A, Silverman IM, Ji X, Gazzara M, Nguyen N, Aguilar G, Martinelli M, Barash Y, Liebhaber SA.

Mol Cell Biol. 2018 Jul 30;38(16).

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LeafCutter vs. MAJIQ and comparing software in the fast-moving field of genomics

Vaquero-Garcia J., Norton S , Barash Y.

Google Scholar | BioRxiv

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2017

Integrative Deep Models for Alternative Splicing

Jha A., Gazzara M., Barash Y.

Bioinformatics, 33 (14): i274-i282 (selected for ISMB2017 proceedings)

Ancient antagonism between CELF and RBFOX families tunes mRNA splicing outcomes

Gazzara, M., Mallory M., Roytenberg R., Lindberg J., Jha A., Lynch K.*, Barash Y.*

Genome Research, 10.1101/gr.220517.117

PRiMeUM: a model for predicting risk of metastasis in Uveal Melanoma

Vaquero-Garcia J., Lalonde E., Ewens K.G, Ebrahimzadeh J., Richard-Yutz J., Shields C.L., Barrera A., Green C.J. Barash Y.*, Ganguly A.*

Investigative Ophthalmology & Visual Science, Vol.58, p4096-4105. 2017

ESRP1 mutations cause hearing loss due to defects in alternative splicing that disrupt cochlear development

Rohacek A.M., Bebee T.W., Tilton R.K., Radens C.M., McDermott-Roe C., Peart N., Kaur M., Zaykaner M., Cieply B., Musunuru K., Barash Y., Germille J.A., Krantz I.D., Carstens R.P., Epstein D.J.

Developmental Cell, accepted

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MAJIQ-SPEL: Web-tool to interrogate classical and complex splicing variations from RNA-Seq data

Green CJ, Gazzara M.R., Barash Y.

Bioinformatics, doi/10.1093

Outlier detection for improved differential splicing quantification from RNA-Seq experiments with replicates

Norton S., Vaquero-Garcia J., Barash Y.

Submitted

Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing

Shinde M. Y., Sidoli S., Kulej K., Mallory M.J., Radens C.M., Reicherter A., Myers R., Barash Y., Lynch K.W., Garcia B.A., Klein P.S.

JBC, in press

Transcriptome analysis of hypoxic cancer cells uncovers intron retention in EIF2B5 as a mechanism to inhibit translation

Brady L.K., Wang H., Radens C.M., Bi Y., Radovich M., Maity A., Ivan C., Ivan M., Barash Y., Koumenis C.

Plos Biology, in press

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2016

A new view of transcriptome complexity and regulation through the lens of local splicing variations

Vaquero-Garcia J., Barrera A., Gazzara, M. González-Vallinas J., Lahens N., Hogenesch J., Lynch K., Barash Y.

ELife 2016;10.7554/eLife.11752

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A SLM2 feedback pathway controls cortical network activity and mouse behavior

Ingrid Ehrmann, Matthew R. Gazzara, Vittoria Pagliarini, Caroline Dalgliesh, Mahsa Kheirollahi-Chadegani, Yaobo Xu, Eleonora Cesari, Marina Danilenko, Marie Maclennan, Kate Lowdon, Tanja Vogel, Piia Keskivali-Bond, Sara Wells, Heather Cater, Philippe Fort, Mauro Santibanez-Koref, Silvia Middei, Claudio Sette, Gavin J. Clowry*, Yoseph Barash*, Mark O. Cunningham*, David J. Elliott*

Cell Reports, Volume 17, Issue 12

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2015

Convergence of acquired mutations and alternative splicing of CD19 enables resistance to CART-19 immunotherapy

Sotillo E., Barrett D., Black K., Bagashev A., Oldridge D., Wu G., Sussman R., Lanauze C., Gazzara M, Martinez N., Ruella M., Harrington C., Chung E., Perazzelli J., Hofmann T., Maude S., Raman P., Barrera A., Gill S., Lacey S., Melenhorst J., Allman D., Jacoby E., Fry T., Mackall C., Barash Y., Lynch K., Maris J, Grupp S.,Thomas-Tikhonenko A.

Cancer Discovery, In press

Hui Y. Xiong, Babak Alipanahi, Leo J. Lee, Hannes Bretschneider, Daniele Merico, Ryan K. C. Yuen, Yimin Hua, Serge Gueroussov, Hamed S. Najafabadi, Timothy R. Hughes, Quaid Morris, Yoseph Barash, Adrian R. Krainer, Nebojsa Jojic, Stephen W. Scherer, Benjamin J. Blencowe, Brendan J. Frey

Science. Vol. 347 no. 6218

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Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation

Martinez N, Agosto L., Qiu J., Mallory M., Gazarra M., Barash Y., Fu X., Lynch K.

Genes & Development Vol. 29 Issue 19

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2014

In silico to in vivo splicing analysis using splicing code models

Gazzara, M., Vaquero-Garcia, J., Lynch, K., Barash, Y.

Methods

Splicing Code Modeling

Barash Y. Vaquero-Garcia J.

Systems Biology of RNA Binding Proteins, Editor Yeo G. W., Springer

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Predicting alternative splicing

Barash Y., Vaquero-Garcia J.

Spliceosomal Pre-mRNA Splicing, Hertel K. J. Editor, Springer

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2013

ESRP1 mutations cause hearing loss due to defects in alternative splicing that disrupt cochlear development

Rohacek A.M., Bebee T.W., Tilton R.K., Radens C.M., McDermott-Roe C., Peart N., Kaur M., Zaykaner M., Cieply B., Musunuru K., Barash Y., Germille J.A., Krantz I.D., Carstens R.P., Epstein D.J.

Developmental Cell, accepted

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2011

Bayesian prediction of

tissue-regulated splicing using RNA sequence and cellular context

Xiong H.Y., Barash Y., Frey B.J.



Bioinformatics. 27:2554–2562

2010

An illuminated view of molecular biology

Barash Y., Wang X.



Genome Biology. 11:307

Deciphering the splicing code

Barash Y., Calarco J.A., Gao W., Pan Q., Wang X., Shai O., Blencowe B.J. Frey B.J.



Nature. 465:53–9

Model-based detection of

alternative splicing signals

Barash Y., Blencowe B.J., Frey B.J.

 

Bioinformatics. 26:i325–i333

2008

A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative

Aznarez I., Barash Y., Shai O.



Genome Research. 18(8):1247–1258

2007

Functional coordination of alternative splicing in the mammalian central nervous system

Fagnani M., Barash Y., Ip J.Y.



Genome Biology. 8:R108

2005

CIS: compound importance sampling method for protein–DNA binding site p-value estimation

Barash Y., Elidan G., Kaplan T. Friedman N.



Bioinformatics. 21:596–600

2004

Comparative analysis of algorithms

for signal quantitation from oligonucleotide microarrays

Barash Y., Dehan E., Krupsky M., Franklin W., Geraci M., Kaminski N.



Bioinformatics. 20:839–846

Sfp1 is a stressand nutrient-sensitive regulator of ribosomal protein gene expression

Marion R.M., Regev A., Segal E.

Barash Y., Koller D., Friedman N. O'Shea E.K.



Proceedings of the National Academy

of Sciences of the United States of America. 101:14315–14322

2003

Modeling dependencies in

Protein-DNA binding sites

Barash Y., Elidan G., Friedman N.

Kaplan T.



Proc. of the 7th Annual International Conference on Research in Computational Molecular Biology (RECOMB)

2002

Context-Specific Bayesian clustering

for Gene Expression Data

Barash Y., Friedman N.



Journal of Computational Biology: 169-191

From Promoter Sequence to Expression: A Probabilistic Framework

Segal E., Barash Y., Simon I., Friedman N. Keller D.



Proc. of the 6th Annual International Conference on Research in Computational Molecular Biology (RECOMB). :263–272

2001

Context-Specific Bayesian clustering

for Gene Expression Data

Barash Y., Friedman N.



Proc. of the 5th Annual International Conference on Research in Computational Molecular Biology (RECOMB)

A Simple Hyper-Geometric Approach

for Discovering Putative Transcription Factor Binding Sites

Barash Y., Bejerano G., Friedman N.



Algorithms in Bioinformatics:

Proc. First International Workshop

(WABI). :278–293

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